76R1. R. Wurth et al. (2025) Circulating tumor cell plasticity determines breast cancer therapy resistance via neuregulin 1–HER3 signaling. Nat Cancer doi: 10.1038/s43018-024-00882-2

75. Y. Wang, J. Nong, B. Lu, Y. Gao, M. Hu, C. Chen, L. Zhang, J. Tan, X. Yang, P. P. Lin, X. Hu, T. Zhang (2024) Disseminated tumor cells in bone marrow as predictive classifiers for small cell lung cancer patients. JNCC 4:335

74. Z. Fu, L. Zhang, R. Chen, J. Zhan, J. Zhong, W. Zheng, J. Zou, P. Wang, X. Deng, A.Y. Lin, D.D. Wang, P. P. Lin, R. He (2024) Biphasic co-detection of melanoma aneuploid tumor cells and tumor endothelial cells in guidance of specifying the field cancerized surgical excision margin and administering immunotherapy. Cancer Letters 598:217099

74R1. “i•FISH组织活检”定量检测“区域性癌变”

74R2. Y. Li, L. Jiang, Y. Chen, J. Zhan, Y. Li, J. Yuan, J. Lu, Z. Zhang, S. Liu, X. Feng, J. Xiong, Y. Jiang, X. Zhang, J. Li, L. Shen (2024) Specific lineage transition of tumor‑associated macrophages elicits immune evasion of ascitic tumor cells in gastric cancer with peritoneal metastasis. Gastric Cancer 27:519

73. Q. Sun, W. Li, D. Yang, P.P. Lin, L. Zhang, H. Guo (2024) The Presence of Small-Size Circulating Tumor Cells Predicts Worse Prognosis in Non–Small Cell Lung Cancer Patients. Arch Pathol Lab Med doi 10.5858/arpa.2023-0455-OA

72. S. Li, S. Luo, N. Wei, A.Y. Lin, D.D. Wang, P.P. Lin, R. Chen, J. Xie, and J. Ren (2023) A rare case of Merkel cell carcinoma on the craniofacial region and characterization of its aneuploid CD31- CTCs and CD31+ CTECs expressing EpCAM or Ki-67. Oral Oncol 147:106602

72R1. G. Ma, J. Wang, J. Fu, R. Chen, M. Liang, M. Li, T. Xia, X. Liu, S. Wang (2023) Heterogeneous circulating tumor cells correlate with responses to neoadjuvant chemotherapy and prognosis in patients with locally advanced breast cancer. Breast Cancer Res Treat 201:27

71. Y. Wang, L. Zhang, J. Tan, Z. Zhang, Y. Liu, X. Hu, B. Lu, Yuan Gao, L. Tong, Z. Liu, H. Zhang, P. P. Lin, B. Li, O. Gires, T. Zhang (2023) Longitudinal detection of subcategorized CD44v6+ CTCs and circulating tumor endothelial cells (CTECs) enables novel clinical stratification and improves prognostic prediction of small cell lung cancer: a prospective, multi-center study. Cancer Lett 571:216337

71R1. Q. Zeng, M. Mousa, A. Nadukkandy, L. Franssens, H. Alnaqbi, F. Alshamsi, H. Safar and P. Carmeliet (2023) Understanding tumour endothelial cell heterogeneity and function from single-cell omics. Nat Rev Cancer 23:544

从TEC单细胞多组学分析看CTEC临床价值 (赛特生物)

70. 蔡桂月，李思锐，刘颖，陈嵘袆，罗素君，林平 (2023) 皮肤肿瘤患者外周血循环肿瘤细胞与循环肿瘤血管内皮细胞检测的临床价值。J Diagn Ther Dermato-Venereol 30:198

69. Y. Wang, Y. Liu, Z. Zhang, B. Lu, Y. Gao, L. Tong, M. Hu, P. P. Lin, B. Li and T. Zhang. (2023) Post-therapeutic circulating tumor cell-associated white blood cell clusters predict poor survival in patients with advanced driver gene-negative non-small cell lung cancer. BMC Cancer 23:578

69R4. 瘤标-iFISH(NC) 全方位检测活性与坏死瘤标阳性CTC、CTEC

69R3. i•FISH 固/液双相肿瘤单细胞挑取系统助力比对性精准CTC-CTEC单细胞测序

69R2. iFISH全自动CTC扫描仪荣获二类医疗器械注册证

69R1. i•FISH全波长抗荧光淬灭剂

68. J. Mi, F. Yang, J, Liu, M. Liu, A.Y. Lin, D.D. Wang, P.P. Lin, Q. Zeng (2022) Case report: Post-therapeutic laryngeal carcinoma patient possessing a high ratio of aneuploid CTECs to CTCs rapidly developed de novo malignancy in pancreas. Front Oncol 12:981907

68R1. T. Han, J. Zhang, D. Xiao, B. Yang, L. Chen, C. Zhai, F. Ding, Y. Xu, X. Zhao, J. Zhao (2022) Circulating Tumor-Derived Endothelial Cells: An Effective Biomarker for Breast Cancer Screening and Prognosis Prediction. J Oncol 2022: 5247423

68R2. J. Curtin, G. Wong, W. Wang, P. Thomson, A.K. Lam, S-W. Choi (2022) A comparison of two methods for the detection of circulating tumor cells in patients with oral cavity cancer. J Oral Pathol Med 51:249

67. M. Li, F. Gao, X, Ren, G. Dong, H. Chen, A.Y. Lin, D.D. Wang, M. Liu, P.P. Lin, S. Shen, H. Jiang, C. Yang, X. Zhang, X. Zhao, Q. Zhu, M. Li, Y Cui, S. Lin (2022) Nonhematogenic circulating aneuploid cells confer inferior prognosis and therapeutic resistance in gliomas. Cancer Sci 113:3535–3546

66. Z. Li, L. Fan, Y. Wu, Y. Niu, X. Zhang, B. Wang, Y. Yao, C. Chen, N. Qi, D. D. Wang, P. P. Lin, D. Tang, W. Gao (2022) Analysis of the prognostic role and biological characteristics of circulating tumor cell-associated white blood cell clusters in non-small cell lung cancer. J Thorac Dis 14:1544-1555

65. A.Y. Lin, D.D. Wang, L. Li and P.P. Lin (2021) Identification and Comprehensive Co-Detection of Necrotic and Viable Aneuploid Cancer Cells in Peripheral Blood. Cancers 13:5108.

64. T. Zhang, L. Zhang, Y. Gao, Y. Wang, Y. Liu, H. Zhang, Q. Wang, F. Hu, J. Li, J. Tan, D.D. Wang, O. Gires, P.P. Lin and B. Li (2021) Role of aneuploid circulating tumor cells and CD31+ circulating tumor endothelial cells in predicting and monitoring anti-angiogenic therapy efficacy in advanced NSCLC. Mol Oncol 15:2891-2909

64R1. H. Zhu, Y. Liu, Y. Feng, L. Zhang, T. Zhang, G. Dong, P. Xing, H. Wang, Y. Shi, X. Hu (2021) Circulating tumor cells (CTCs)/circulating tumor endothelial cells (CTECs) and their subtypes in small cell lung cancer: Predictors for response and prognosis. Thorac Cancer 12:2749

64R2. J. Goveia et al. (2020) An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates. Cancer Cell 37:21-36.

64R3. S Luo, Y Ou, T Zheng, H Jiang, Y Wu, J Zhao and Z Zhang (2021) Optimal Strategy for Colorectal Cancer Patients’ Diagnosis Based on Circulating Tumor Cells and Circulating Tumor Endothelial Cells by Subtraction Enrichment and Immunostaining-Fluorescence In Situ Hybridization Combining with CEA and CA19-9. J. Oncol 1517488

63. Y. Chen, Y. Li, C. Qi, C. Zhang, D. Liu, Y. Deng, Y. Fu, V.S. Khadka, D.D. Wang, S. Tan, S. Liu, Z. Peng, J. Gong, P.P. Lin, X. Zhang, J. Li, Y. Li, L. Shen (2021) Dysregulated KRAS gene-signaling axis and abnormal chromatin remodeling drive therapeutic resistance in heterogeneous-sized circulating tumor cells in gastric cancer patients. Cancer Lett 517:78-87

63R1. D. Loreth, M. Schuette, J. Zinke, M. Mohme, A. Piffko, S. Schneegans, et al. (2021) CD74 and CD44 Expression on CTCs in Cancer Patients with Brain Metastasis. Intl J Mol Sci 22:6993

63R2. A. Liu et al. (2021) Silencing ZIC2 abrogates tumorigenesis and anoikis resistance of non-small cell lung cancer cells by inhibiting Src/FAK signaling. Mol Ther Oncolytics 22:195

62. P.P. Lin (2021) Chapter: Liquid Biopsy Analysis of Circulating Tumor Biomarkers in Lung Cancer, in the book “Lung Cancer – Modern Multidisciplinary Management” edited by Henry S. Park, Yale University School of Medicine; published by IntechOpen Publisher, London, UK.

62R1. C. Xing, Y. Li, C. Ding, S. Wang, H. Zhang, L. Chen, P Li, M. Dai (2021) CD44+ Circulating Tumor Endothelial Cells Indicate Poor Prognosis in Pancreatic Ductal Adenocarcinoma After Radical Surgery: A Pilot Study. Cancer Manag Res 13:4417-4431

61. H. Cheng, S. Wang, W. Luan, X. Ye, S, Dou, Z. Tang, H. Zhou, P.P. Lin, Y. Li, H. Cui, and X. Chang (2021) Combined detection and subclass characteristics analysis of CTCs and CTECs by SE-iFISH in ovarian cancer. Chin J Cancer Res 33:256-270

61R. H. Cheng et al. (2021) Preliminary Safety and Potential Effect of 6B11-OCIK Adoptive Cell Therapy Against Platinum-Resistant Recurrent or Refractory Ovarian Cancer. Front Immunol 12:707468.

60. Y.Hong, J. Si, J. Zhang, Y. Xiong, J. Zhang, P. Lin, J. Fang, Y. Yang, C. Lv and Y. Ma (2021) Small Cell Size Circulating Aneuploid Cells as a Biomarker of Prognosis in Resectable Non-Small Cell Lung Cancer. Front Oncol 11:590952

59．P. P. Lin (2020) Aneuploid Circulating Tumor-Derived Endothelial Cell (CTEC): A Novel Versatile Player in Tumor Neovascularization and Cancer Metastasis. Cells 9:1539

59R. Y. Lei, N. Sun, G. Zhang, C. Liu, Z. Lu, J. Huang, C. Zhang, R. Zang, R. Che, S. Mao, L. Fang, X. Wang, S. Zheng, J. He (2020) Combined detection of aneuploid circulating tumor-derived endothelial cells and circulating tumor cells may improve diagnosis of early stage non-small-cell lung cancer. Clin Transl Med e128

58. Y. Chen, C. Qi, J. Yuan, D. Liu, Z. Peng, X. Zhang, J. Li, P.P. Lin, Y. Li, L. Shen (2020) Elevated PD-L1 and HER2 expression on aneuploid carcinoma cells in malignant ascites accelerates tumor cell immune evasion in gastrointestinal cancer patients. Cancer Res 80:5381a

57.  程洪艳，李一林，王书航，刘颖，王丹丹，林平，昌晓红 (2020) 应用SE-iFISH同步联合检测异倍体CTC与CTEC的重要临床意义。《临床实验室》(Clinical Laboratory) 14(5):43-48

56. L. Zhang, X. Zhang, Y. Liu, T. Zhang, Z. Wang, M. Gu, Y. Li, D.D. Wang, W. Li, P.P. Lin (2020) PD-L1+ aneuploid circulating tumor endothelial cells (CTECs) exhibit resistance to the checkpoint blockade immunotherapy in advanced NSCLC patients. Cancer Lett 469:355-366

55. Y. Zhao, J. Li, D. Li, Z. Wang, J. Zhao, X. Wu, Q. Sun, P.P. Lin, P. Plum, A. Damanakis, F. Gebauer, M. Zhou, Z. Zhang, H. Schlosser, K-W Jauch, P.J. Nelson, C.J. Bruns (2020) Tumor biology and multidisciplinary strategies of oligometastasis in gastrointestinal cancers. Semin Cancer Biol 60:334-343

55R. G. Ma, Y. Jiang, M. Liang, J. Li, J. Wang, X. Mao, J. S. Veeramootoo, T. Xia, X. Liu, S. Wang (2020) Dynamic monitoring of CD45-/CD31+/DAPI+ circulating endothelial cells aneuploid for chromosome 8 during neoadjuvant chemotherapy in locally advanced breast cancer. Ther Adv Med Oncol 12:1-14

54. X. Liu, J. Li, B. L. Cadilha, A. Markota, C. Voigt, Z. Huang, P. P. Lin, D. D. Wang, J. Dai, G. Kranz, A. Krandick, D. Libl, H. Zitzelsberger, I. Zagorski, H. Braselmann, M. Pan, S. Zhu,Y. Huang, S. Niedermeyer, C. A. Reichel, B. Uhl, D. Briukhovetska, J. Suárez, S. Kobold, O. Gires, and H. Wang (2019) Epithelial-type systemic breast carcinoma cells with a restricted mesenchymal transition are a major source of metastasis (SA Highlights). Science Advances 5, eaav4275

53. Y. Wang, Y. Liu, L. Zhang, L. Tong, Y. Gao, F. Hu, P. P. Lin, B. Li, T. Zhang (2019) Vimentin expression in circulating tumor cells (CTCs) associated with liver metastases predicts poor progression-free survival in patients with advanced lung cancer. J Cancer Res Clin Oncol 145:2911-2920

53R1. Z. Ye, Y. Ding, Z. Chen, Z. Li, S. Ma, Z. Xu, L. Cheng, X. Wang, X. Zhang, N. Ding, Q. Zhang, and Q. Qian (2019) Detecting and phenotyping of aneuploid circulating tumor cells in patients with various malignancies. Cancer Biol Ther 20:546

53R2. Y. Zhang, J. Li, Li. Wang, P. Meng, J. Zhao, P. Hang, J. Xia, J. Xu, Li. Wang, F. Shen, A. Zheng, F. Zhou and R. Fan (2019) Clinical significance of detecting circulating tumor cells in patients with esophageal squamous cell carcinoma by EpCAM-independent enrichment and immunostaining-fluorescence in situ hybridization. Mol Med Rep 20:1551

52. Y. Li, X. Zhang, D. Liu, J. Gong, D. Wang, S. Li, Z. Peng, Y. Li, X. Wang, P. Lin, M. Li, and L. Shen (2018) Evolutionary expression of HER2 conferred by chromosome aneuploidy on circulating gastric cancer cells contributes to developing targeted and chemotherapeutic resistance (CCR Highlights). Clin Cancer Res 24:5261-71

51. P. Lin, J. Li, D. Wang, O. Gires, H. Wang (2018) EpCAM differentially expressed on circulating and disseminated tumor cells promotes tumor metastasis in breast cancer patients. Cancer Res 78:1059a

50. J. Zhang, H. Shi, T. Jiang, Z. Liu, P.P. Lin, and N. Chen (2018) Circulating tumor cells with karyotyping as a novel biomarker for diagnosis and treatment of nasopharyngeal carcinoma. BMC Cancer 18:1133

49. P. Lin (2018) Aneuploid CTC and CEC. Diagnostics 8(2):26(1-13)

48. L. Wang, Y. Li, J. Xu, A. Zhang, X. Wang, R. Tang, X. Zhang, H. Yin, M. Liu, D. Wang, P. Lin, L. Shen, J. Dong (2018) Quantified postsurgical small cell size CTCs and EpCAM+ circulating tumor stem cells with cytogenetic abnormalities in hepatocellular carcinoma patients determine cancer relapse. Cancer Lett 412:99-107

48R1. X. Liu, Z. Zhang, B. Zhang, Y. Zheng, C. Zheng, B. Liu, S. Zheng, K. Dong, R. Dong (2018) Circulating tumor cells detection in neuroblastoma patients by EpCAM-independent enrichment and immunostaining-fluorescence in situ hybridization. EBioMedicine 35:244

48R2. Z. Su, J. Zhao, S. KE, J. Zhang, X. Liu, Y. Wang, Q. Sun and Q. Pan (2018) Clinical significance of circulating tumor cells via combined whole exome sequencing in early stage cancer screening: A case report. Exp Ther Med 16:2527

47. X. Li, Y. Zhang, J. Ding, M. Wang, N. Li, H. Yang, K. Wang, D. Wang, P. Lin, M. Li, Z. Zhao, and P. Liu (2017) Clinical significance of detecting CSF-derived tumor cells in breast cancer patients with leptomeningeal metastasis. Oncotarget 9:2705-14

46. P. Lin, O. Gires, D. Wang, L. Li and H. Wang (2017) Comprehensive in situ co-detection of aneuploid circulating endothelial and tumor cells. Sci Rep 7:9789

46R. Y. Xu, T. Qin, J. Li, X. Wang, C. Gao, C. Xu, J. Hao, J. Liu, S. Gao and H. Ren (2017) Detection of Circulating Tumor Cells Using Negative Enrichment Immunofluorescence and an In Situ Hybridization System in Pancreatic Cancer. Int J Mol Sci 18:622

45. 由磊，赵烨，阚秀，李一林，王东民，张爱群，王红霞，刘颖，王丹丹，林平，郑直 (2017) 同步原位检测 CTC 多重瘤标蛋白表达与染色体异倍体的意义及应用。《临床与实验病理学杂志》 (J Clin Exp Pathol) 33:297-302

45R. W. Wu, Z. Zhang, X. Gao, Z. Shen, Y. Jing, H. Lu, H. Li, X. Yang, X. Cui, Y. Li, Z. Lou, P. Liu, C. Zhang, W. Zhang (2017) Clinical significance of detecting circulating tumor cells in colorectal cancer using subtraction enrichment and immunostaining-fluorescence in situ hybridization (SE-iFISH) Oncotarget 8:21639

44. Y. Li, X. Zhang, D. Liu, J. Gong, D.D. Wang, P.P. Lin, and L. Shen (2017) Dynamic acquisition of HER2 expression on circulating tumor cells in gastric cancer patients correlates to developing therapeutic resistance. Cancer Res 77:3795a

44R. Y. Sheng, T. Wang, H. Li, Z. Zhang, J. Chen, C. He, Y. Li, Y. Lv, J. Zhang, C. Xu, Z. Wang, C. Huang and L. Wang (2017) Comparison of analytic performances of Cellsearch and iFISH approach in detecting circulating tumor cells. Oncotarget 8:8801

43. H. Wang, N. Stoecklein, P. Lin and O. Gires (2017) Circulating and disseminated tumor cells: diagnostic tools and therapeutic targets in motion (Review). Oncotarget 8:1884-1912

42. Y. Li, X. Zhang, J. Gong, Q. Zhang, J. Gao, Y. Cao, D. D. Wang, P.P. Lin, and L. Shen (2016) Aneuploidy of chromosome 8 in circulating tumor cells correlates with prognosis in patients with advanced gastric cancer. Chin J Cancer Res 28:579-588

42R. Y. Gao, Y. Zhu, Z. Zhang, C. Zhang, X. Huang and Z. Yuan (2016) Clinical significance of pancreatic circulating tumor cells using combined negative enrichment and immunostaining-fluorescence in situ hybridization. J Exp Clin Cancer Res 35:66

41. P. Lin (2016) NGS analysis of the single CTC or DTC isolated and subtyped by the integrated subtraction enrichment and immunostaining-FISH. Cancer Res 76:489a

41R. F. Gao, Y. Cui, H. Jiang, D. Sui, Y. Wang, Z. Jiang, J. Zhao, S. Lin (2016) Circulating tumor cell is a common property of brain glioma and promotes the monitoring system. Oncotarget 7:71330-71340

40. P. Lin (2015) Integrated EpCAM-independent subtraction enrichment and iFISH strategies to detect and classify disseminated and circulating tumors cells. Clin Transl Med 4(38):1-7

39. F. Ge, H. Zhang, D. Wang, L. Li and P. Lin (2015) Enhanced detection and comprehensive in situ phenotypic characterization of circulating and disseminated heteroploid epithelial and glioma tumor cells. Oncotarget 6 (29): 27049-27064

38. P. Lin, L. Li, and D. Wang (2015) A novel integrated iFISH technology to detect and characterize non-hematopoietic heteroploid CTC subtypes with or without expressing vimentin or other tumor biomarkers. Cancer Res 75:557

37. J. Jiang, D. Wang,  M. Yang, D. Chen, L. Pang, S. Guo, J. Cai, J.P. Wery, L. Li, H. Li,and P. Lin (2015) Comprehensive characterization of chemotherapeutic efficacy on metastases in the established gastric neuroendocrine cancer patient derived xenograft model. Oncotarget 6(17):15639-15651

36. Y.Li, X. Zhang, S. Ge, J. Gao, J. Gong, M. Lu, Q. Zhang, Y. Cao, D. Wang, P. Lin, L. Shen (2014) Clinical Significance of Phenotyping and Karyotyping of Circulating Tumor Cells in Patients with Advanced Gastric Cancer. Oncotarget  5(16):6594-6602

35. R. Ran, L. Li, M. Wang, S. Wang, Z. Zheng, and P. Lin (2013) Determination of EGFR mutation in single cells microdissected from enriched lung tumor cells in peripheral blood. Anal. Bioanal. Chem. 405(23):7377-7382

34. J. Jiang, D.D. Wang, M. Yang, D. Chen, S. Guo, J. Cai, L. Li, J-P. Wery, P. Lin, and H. Li (2013) Metastatic PDX modeling displays correlation between CTC and metastatic potential, both inhibited by chemotherapy. Mol. Cancer Ther. 12:157

33. Q. Chen, F. Ge, W. Cui, F. Wang, Z. Yang, Y. Guo, L. Li, R. Bremner, and P. Lin (2013) Lung Cancer Circulating Tumor Cells Isolated by the EpCAM-Independent Enrichment Strategy Correlate with Cytokeratin 19-Derived CYFRA21-1 and Pathological Staging. Clin. Chim. Acta 419:57-61

32. 杨俊俊，徐兴祥，闭凌峰，林平，钱桂生 (2012) 免疫磁珠阴性法富集恶性胸腔积液中肿瘤细胞方法的建立。《中华结核和呼吸杂志》(Chin J Tuberc Respir Dis) 35(9):673-678

31. X. Zhou, L. Li, H. Hao, S. Wang, Z. Guo, M. Wang, L. Zhang, W. Zhong, R. Ran, X. Zhang, L. Xu, and P. Lin (2010) Circulating tumor cells as a prognostic and predictive indicator in advanced lung cancer patients. Oncol. Progress 8(5):484-490

30. C. Wu, H. Hao, L. Li, X. Zhou, Z. Guo, L. Zhang, X. Zhang, W. Zhong, H. Guo, R. Bremner, and P. Lin (2009) Preliminary investigation of the clinical significance of detecting circulating tumor cells enriched from lung cancer patients. J. Thorac. Oncol. 4:30-36

29. P. Lin, C. Lavoie, T. Fischer, H. Huang, and M. Farquhar (2009) Calnuc plays a role in dynamic distribution of Galphai but not Gbeta subunits and modulates ACTH secretion in AtT-20 neuroendocrine secretory cells. 
Mol. Neurodegener. 4:1-16

28. L. Li, X. Zhou, H. Hao, M. Wang, Z. Guo, S. Wang, X. Xing, G. Harvie, E. Vuong, W. Shi, M. Tang, J. Rao, T. Reid, R. Bremner, P. Lin, J. Xu (2008) Detection of circulating tumor cells in newly diagnosed or relapsed lung cancer patients and the significance of CTC enumeration in patient staging. Cancer Res. 68:3691

27. D. Wang, Y, Liu, Y. Liu, C. Wang, H. Bao, H. Hao, S. Wang, Y. Zhang, H. Yu, X. Xing, G. Harvie, E. Vuong, J. Rao, T. Reid, P. Lin, J. Xu (2008) Enrichment and detection of circulating tumor cells in breast cancer patients. Cancer Res. 68:3692

26. H. Guo, H. Hao, Z. Li, Y. Zhu, J. Sun, F. Ge, S. Wang, X. Xing, G. Harvie, E. Vuong, J. Rao, R. Bremner, T. Reid, P. Lin, J. Xu (2008) Preliminary investigation of lung cancer CTC distribution in patient body circulation. Cancer Res. 68:3694

25. Y, Chen, H. Bao, C. Zhou, X. Xing, G. Harvie, E. Vuong, J. Rao, T. Reid, H. Qiu, Y. Xiao, H. Wu, M. Mei, C. Lu, P. Lin and J. Xu (2008) Detection of circulating tumor cell in patients with colorectal cancer and its potential implication. Cancer Res. 68:3696

24. X. Zhou, L. Li, M. Wang, L. Zhang, P. Lin and J. Xu (2008) Circulating tumor cells (CTC) as a prognostic and predictive factor in lung cancer patients. J Clin Oncol 26(15):22201

23. C. Ren, P. He, J. Zhang, Z. Zheng, Y. Xu, L. Zhou, H. Qiao, C. Wang, P. Zhao, W. Shi, M. Tang, P. Lin, and J. Xu (2007) Detecting circulating tumor cells in peripheral blood of pancreatic cancer patients using negative selection strategy. Cancer Res. 67:5445

22. W. Shi, T. Reid, M. Tang, G. Harvie, H. Tao, G. Tao, P. Lin, and J. Xu (2007) Detection of circulating cancer cells from lung cancer patient blood samples and correlation with anti-cancer therapy. Cancer Res. 67:5444

21. H. Yu, P. Lin, Y. Xu, Y. Zhou, Q. Sun, and J. Xu (2007) Breast cancer and circulating tumor cells (Review). Chn. J. Med. Lab. Tech. 8(3):215-218

20. Y. Chen, P. Lin, S. Qiu, XX. Peng, K. Loi, MG Farquhar and JY. Zhang (2007) Autoantibodies to Ca2+ binding protein Calnuc is a potential marker in colon cancer detection. Int. J. Oncol. 30(5):1137-44

19. P. Lin, F. Li, Y. Zhang, H. Huang, G. Tong, M. Farquhar and H. Xu (2007) Calnuc binds to Alzheimer’s beta-amyloid precursor protein and affects its biogenesis. J. Neurochem. 100:1505-1514

18. Y. Chen, P. Lin, K. Looi, R. Megliorino, and J. Zhang (2005) Autoantibodies to calcium binding protein Calnuc might be a potential marker in colon cancer detection. Cancer Res. 65:561

17. P. Lin, C. Ren, X. Zhao, L. Li, Y. Qiao , G. Harve, H. Tao, E. Vuong, G. Tao, M, Huang, L. Wu, and J. Xu (2005) Role of detecting circulating tumor cell in clinical cancer diagnosis and therapy. Chn. J. Lab. Tech. 1 (1):1-6

16. Y-W. Zhang, W-J Luo, H. Wang, P. Lin, K.S. Vetrivel, F. Liao, F. Li, P.C. Wong, M.G. Farquhar, G. Thinakaran, and H. Xu (2005) Nicastrin is critical for stability and trafficking but not association of other presenilin/γ-secretases components. J. Biol. Chem. 280:17020-17026

15. C. Lavoie, T. Meerloo, P. Lin , and M.G. Farquhar (2002) Calnuc, an EF-Hand Ca2+-binding protein, is stored and processed in the Golgi and secreted by the constitutive-like pathway in AtT-20 cells. Mol. Endocrinol. 16:2462-2474

14. T.S.Weiss, C.E. Chamberlain, T. Takeda, P. Lin, K.M. Hahn, and M.G. Farquhar (2001) Galphai3 binding to calnuc on Golgi membranes in living cells monitored by fluorescence resonance energy transfer (FRET) of green fluorescent protein fusion proteins. Proc. Natl. Acad. Sci. USA. 98:14961-14966

13. P. Lin, T. Fischer, T. Weiss, and M.G. Farquhar (2000) Calnuc, an EF-hand Ca2+ binding protein, specifically interacts with the C-terminal alpha5-helix region of Galphai3. Proc. Natl. Acad. Sci. USA. 97:674-679

12. P. Lin, C. Lavoie, T. Fischer and M.G. Farquhar (2000) Calnuc regulates ACTH secretion in AtT-20 cells. Mol. Biol. Cell 11:50

11. P. Lin, Y. Yao, R. Hofmeister, R.Y. Tsien and M.G. Farquhar (1999) Overexpression of CALNUC (nucleobindin) increases agonist and thapsigargin relesable Ca2+ storage in the Golgi. J. Cell Biol. 145:279-289

10. P. Lin, T. Fischer, T. Weiss, and M.G. Farquhar (1999) Calnuc, an EF-hand Ca2+ binding protein, specifically interacts with the C-terminal region of Galphai3. Mol. Biol. Cell 10:418

9.P. Lin, H. Le-Niculescu, R. Hofmeister, J.M. McCaffery, M. Jin, H. Hennemann, T. McQuistan, L. De Vries, and M.G. Farquhar (1998) The mammalian Ca2+ binding protein, nucleobindin (CALNUC), is a Golgi resident protein. J. Cell Biol. 141:1515-1527

8.P. Lin, Y. Yao, R. Hofmeister, R.Y. Tsien and M.G. Farquhar (1998) Overexpression of CALNUC increases agonist and thapsigargin relesable Ca2+ storage in the Golgi. Mol. Biol. Cell 9:99

7. H. Le-Niculescu, P. Lin, M. Jin, H. Hennemann, D. Heinegard, T. McQuistan, J. M. McCaffery, N. Watson, L. De Vries, and M.G. Farquhar (1997) Characterization of a Golgi-associated EF-hand/ Ca2+ binding protein that interacts with heterotrimeric Galphai protein subunits. Mol. Biol. Cell 8:338

6. Y-P. Li, G. Curley, M. Lopez, M Chavez, R. Glew, A. Aragon, H. Kumar, and O.G. Baca (1996) Protein-tyrosine phosphatase activity of Coxiella Burnetii that inhibits human neutrophils. Acta Virologica 40:263-272

5. P. Lin, C. Mold, and T.W. DuClos (1995) Characterization of the C-reactive protein (CRP) receptor on the human monocytic cell line THP-1 (704). Immunol. Today 16(7):305-62

4. O.G. Baca, Y-P. Li, and H. Kumar  (1994) Survival of the Q fever agent Coxiella Burnetii in the phagolysosome. Trends in Microbiol. 2(12):476-480

3. Y-P. Li, C. Mold, and T.W. DuClos (1994) Sublytic Complement Attack Exposes C-Reactive Protein Biding Sites on Cell Membranes. J. Immunol. 152:2995-3005

2. T. Nakagaki, P. Lin, and W. Kisiel (1992) Activation of human factor VII by the prothrombin activator from the venom of Oxyuranus Scutellatus(taipan snake). Thrombosis Res. 65:105-116

1. P. Lin, Q.S. Lin, and S.Q. Nie (1992) Primary study of application of liposome immunolysis assay on drug monitoring. Prog. Clin. Biochem.p515-516. Editors: K. Miyai, T. Kanno, and E. Ishikawa. Excerpta Medica Publishing.