我们与国内外众多合作单位联合发表的部分文章与摘要(包括 CTCCTEC,肿瘤细胞与分子生物学,脑神经学,内分泌学,免疫学,血液学,病原微生物学,C-反应蛋白 CRP,免疫脂质体溶破技术应用等



  • 文章索引

  • 中文推送(点击推送题目下载)

    • 73. Q. Sun, W. Li, D. Yang, P.P. Lin, L. Zhang, H. Guo (2024) The Presence of Small-Size Circulating Tumor Cells Predicts Worse Prognosis in Non–Small Cell Lung Cancer Patients. Arch Pathol Lab Med doi 10.5858/arpa.2023-0455-OA

      关键词: 小细胞CTC、大细胞CTEC、NSCLC、预后
      合作单位:首都医科大学肿瘤医学院 (北京世纪坛医院)、北京天坛医院、北京胸科医院、美国纽约中医药大学、赛特生物
    • 73R1. “i•FISH组织活检”定量检测“区域性癌变”

      关键词: iFISH组织活检、iFISH液体活检、区域性癌变细胞、肿瘤复发
      合作单位:赛特生物
    • 72. S. Li, S. Luo, N. Wei, A.Y. Lin, D.D. Wang, P.P. Lin, R. Chen, J. Xie, and J. Ren (2023) A rare case of Merkel cell carcinoma on the craniofacial region and characterization of its aneuploid CD31- CTCs and CD31+ CTECs expressing EpCAM or Ki-67. Oral Oncol 147:106602

      关键词: 皮肤癌、Ki67+ CTC/CTEC、SE-iFISH
      合作单位:南方医科大学皮肤病医院 (广州)、赛特生物
    • 71. Y. Wang, L. Zhang, J. Tan, Z. Zhang, Y. Liu, X. Hu, B. Lu, Yuan Gao, L. Tong, Z. Liu, H. Zhang, P. P. Lin, B. Li, O. Gires, T. Zhang (2023) Longitudinal detection of subcategorized CD44v6+ CTCs and circulating tumor endothelial cells (CTECs) enables novel clinical stratification and improves prognostic prediction of small cell lung cancer: a prospective, multi-center study. Cancer Lett 571:216337

      关键词:小细胞肺癌 SCLC、干细胞标志物CD44v6、CD44v6+ CTEC与CTC、肝转移/脑转移及医疗分层、预后、慢病毒感染高表达CD44v6、肿瘤转移体外实验、转化医学
      合作单位:首都医科大学附属北京胸科医院、中国医学科学院暨北京协和医学院肿瘤医院、国家癌症中心、国家肿瘤临床医学研究中心、首医北京潞河医院、德国慕尼黑大学医学中心、赛特生物
    • 71R1. Q. Zeng, M. Mousa, A. Nadukkandy, L. Franssens, H. Alnaqbi, F. Alshamsi, H. Safar and P. Carmeliet (2023) Understanding tumour endothelial cell heterogeneity and function from single-cell omics. Nat Rev Cancer 23:544

      从TEC单细胞多组学分析看CTEC临床价值 (赛特生物)

      关键词:肿瘤血管内皮细胞TEC、循环肿瘤血管内皮细胞CTEC、RNA单细胞测序 (scRNA-seq)、比对性精准靶向单细胞多组学分析
      合作单位:比利时鲁汶天主教大学肿瘤中心 (KU Leuven)、丹麦奥胡斯大学 (Aarhus Univ)、阿联酋哈利法科技大学 (Khalifa Univ)
    • 70. 蔡桂月,李思锐,刘颖,陈嵘袆,罗素君,林平 (2023) 皮肤肿瘤患者外周血循环肿瘤细胞与循环肿瘤血管内皮细胞检测的临床价值。J Diagn Ther Dermato-Venereol 30:198

      关键词: 皮肤癌、恶性黑色素瘤、Ki67+/SCCA1+ CTC 与CTEC、SE-iFISH
      合作单位:南方医科大学皮肤病医院 (广州)、赛特生物
    • 69. Y. Wang, Y. Liu, Z. Zhang, B. Lu, Y. Gao, L. Tong, M. Hu, P. P. Lin, B. Li and T. Zhang. (2023) Post-therapeutic circulating tumor cell-associated white blood cell clusters predict poor survival in patients with advanced driver gene-negative non-small cell lung cancer. BMC Cancer 23:578

      关键词:非小细胞肺癌 NSCLC、驱动基因突变阴性、CTC-WBC细胞团、SE-iFISH
      合作单位:首都医科大学附属北京胸科医院、赛特生物
    • 69R4. 瘤标-iFISH(NC) 全方位检测活性与坏死瘤标阳性CTC、CTEC

      关键词:区分与原位联合检测坏死及活性异倍体CTC、CTEC;PD-L1/HER2 等瘤标蛋白表达;实时监测疗效与肿瘤耐药;坏死与活性比对性单细胞测序
      合作单位:赛特生物
    • 69R3. i•FISH 固/液双相肿瘤单细胞挑取系统助力比对性精准CTC-CTEC单细胞测序

      关键词:比对性精准靶向单细胞测序与分析;CTC及CTEC亚类细胞;SE-iFISH
      合作单位:赛特生物
    • 69R2. iFISH全自动CTC扫描仪荣获二类医疗器械注册证

      关键词:全自动6-通道 3D 扫描、全波长抗荧光淬灭剂
      合作单位:赛特生物
    • 69R1. i•FISH全波长抗荧光淬灭剂

      关键词:全波长光谱荧光染料 (包括远红外、近红外),抗淬灭,增强荧光亮度,免疫荧光染色及染色体荧光原位杂交
      合作单位:赛特生物
    • 68. J. Mi, F. Yang, J, Liu, M. Liu, A.Y. Lin, D.D. Wang, P.P. Lin, Q. Zeng (2022) Case report: Post-therapeutic laryngeal carcinoma patient possessing a high ratio of aneuploid CTECs to CTCs rapidly developed de novo malignancy in pancreas. Front Oncol 12:981907

      关键词:MRD、高比值CTEC/CTC、预测肿瘤发生
      合作单位:广州中山大学五院、中国医学科学院暨北京协和医学院肿瘤医院、国家癌症中心、国家肿瘤临床医学研究中心、分子肿瘤学国家重点实验室、赛特生物
    • 68R1. T. Han, J. Zhang, D. Xiao, B. Yang, L. Chen, C. Zhai, F. Ding, Y. Xu, X. Zhao, J. Zhao (2022) Circulating Tumor-Derived Endothelial Cells: An Effective Biomarker for Breast Cancer Screening and Prognosis Prediction. J Oncol 2022: 5247423

      关键词:CD31+ CTEC、乳腺癌筛查、预后
      合作单位:西安交大医学院附属医院、福建医科大学附属泉州第一医院、上海张江转化医学中心、上海宝藤医学检验所、赛特生物
    • 68R2. J. Curtin, G. Wong, W. Wang, P. Thomson, A.K. Lam, S-W. Choi (2022) A comparison of two methods for the detection of circulating tumor cells in patients with oral cavity cancer. J Oral Pathol Med 51:249

      关键词:SE-iFISH与细胞筛过滤法 (ISET) 方法学比较、 口腔癌、术前/术中/术后动态监测
      合作单位:澳大利亚Griffith大学医学院、James Cook大学医学院、香港大学、赛特生物
    • 67. M. Li, F. Gao, X, Ren, G. Dong, H. Chen, A.Y. Lin, D.D. Wang, M. Liu, P.P. Lin, S. Shen, H. Jiang, C. Yang, X. Zhang, X. Zhao, Q. Zhu, M. Li, Y Cui, S. Lin (2022) Nonhematogenic circulating aneuploid cells confer inferior prognosis and therapeutic resistance in gliomas. Cancer Sci 113:3535–3546

      关键词:胶质瘤、血脑屏障破坏、CD31- CTC 及CD31+ CTEC、治疗耐受、预后
      合作单位:中国国家神经系统疾病研究中心、首都医科大学附属北京天坛医院神经外科、北京脑肿瘤研究中心、浙江省人民医院神经外科、美国俄克拉荷马州大学医学中心、赛特生物
    • 66. Z. Li, L. Fan, Y. Wu, Y. Niu, X. Zhang, B. Wang, Y. Yao, C. Chen, N. Qi, D. D. Wang, P. P. Lin, D. Tang, W. Gao (2022) Analysis of the prognostic role and biological characteristics of circulating tumor cell-associated white blood cell clusters in non-small cell lung cancer. J Thorac Dis 14:1544-1555

      关键词: CTC-WBC 细胞团、较差预后、非小细胞肺癌 NSCLC
      合作单位:复旦大学附属上海华东医院、赛特生物
    • 65. A.Y. Lin, D.D. Wang, L. Li and P.P. Lin (2021) Identification and Comprehensive Co-Detection of Necrotic and Viable Aneuploid Cancer Cells in Peripheral Blood. Cancers 13:5108.

      关键词:检测活性与坏死异倍体CTC及CTEC、实时评估疗效、检测MRD、SE-iFISH (NC)
      合作单位:赛特生物
    • 64. T. Zhang, L. Zhang, Y. Gao, Y. Wang, Y. Liu, H. Zhang, Q. Wang, F. Hu, J. Li, J. Tan, D.D. Wang, O. Gires, P.P. Lin and B. Li (2021) Role of aneuploid circulating tumor cells and CD31+ circulating tumor endothelial cells in predicting and monitoring anti-angiogenic therapy efficacy in advanced NSCLC. Mol Oncol 15:2891-2909

      关键词:肿瘤新生血管抑制剂贝伐单抗、CTC与CTEC、EMT与EndoMT、桑基定向分析、疗效预测与评估、实时监测耐药、NSCLC
      合作单位:首都医科大学附属北京胸科医院、德国慕尼黑大学医学中心、赛特生物
    • 64R1. J. Goveia et al. (2020) An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates. Cancer Cell 37:21-36.

      关键词:肿瘤血管内皮细胞TEC、单细胞RNA测序、TEC亚类、免疫监视、NSCLC
      合作单位:广东中山大学、华大基因、德国、比利时等多国科研团队
    • 64R2. S Luo, Y Ou, T Zheng, H Jiang, Y Wu, J Zhao and Z Zhang (2021) Optimal Strategy for Colorectal Cancer Patients’ Diagnosis Based on Circulating Tumor Cells and Circulating Tumor Endothelial Cells by Subtraction Enrichment and Immunostaining-Fluorescence In Situ Hybridization Combining with CEA and CA19-9. J. Oncol 1517488

      关键词:结直肠癌、辅助诊断、SE-iFISH、CTC及CTEC、CEA及CA19-9
      合作单位: 福建医科大学附属泉州第一医院、上海宝藤生物、赛特生物
    • 63. Y. Chen, Y. Li, C. Qi, C. Zhang, D. Liu, Y. Deng, Y. Fu, V.S. Khadka, D.D. Wang, S. Tan, S. Liu, Z. Peng, J. Gong, P.P. Lin, X. Zhang, J. Li, Y. Li, L. Shen (2021) Dysregulated KRAS gene-signaling axis and abnormal chromatin remodeling drive therapeutic resistance in heterogeneous-sized circulating tumor cells in gastric cancer patients. Cancer Lett 517:78-87

      关键词:iFISH CTC单细胞测序、大/小细胞 CTC、改良型MDA全基因组扩增、赛特固/液双相单细胞显微分离、预后、耐药、胃癌
      合作单位:北京大学肿瘤中心、北京肿瘤医院、美国夏威夷大学医学院、泰州健为医学、赛特生物
    • 63R1. D. Loreth, M. Schuette, J. Zinke, M. Mohme, A. Piffko, S. Schneegans, et al. (2021) CD74 and CD44 Expression on CTCs in Cancer Patients with Brain Metastasis. Intl J Mol Sci 22:6993

      关键词:肺癌/乳腺癌/恶性黑色素瘤脑转移预测、CD44+/CD74+ 双阳CTC
      合作单位:德国汉堡大学医学中心、德国癌症研究中心等
    • 63R2. A. Liu et al. (2021) Silencing ZIC2 abrogates tumorigenesis and anoikis resistance of non-small cell lung cancer cells by inhibiting Src/FAK signaling. Mol Ther Oncolytics 22:195

      关键词:锌指蛋白、非小细胞肺癌、CTC、SE-iFISH
      合作单位:中南大学湘雅医院、国家遗传病临床研究中心、中山大学江门中心医院、广东医科大学、赛特生物
    • 62. P.P. Lin (2021) Chapter: Liquid Biopsy Analysis of Circulating Tumor Biomarkers in Lung Cancer, in the book “Lung Cancer – Modern Multidisciplinary Management” edited by Henry S. Park, Yale University School of Medicine; published by IntechOpen Publisher, London, UK.

      关键词:肺癌液体活检、CTC及CTEC、CTC-derived xenograft (CDX)
      合作单位:赛特生物
    • 62R1. C. Xing, Y. Li, C. Ding, S. Wang, H. Zhang, L. Chen, P Li, M. Dai (2021) CD44+ Circulating Tumor Endothelial Cells Indicate Poor Prognosis in Pancreatic Ductal Adenocarcinoma After Radical Surgery: A Pilot Study. Cancer Manag Res 13:4417-4431

      关键词:胰腺癌、CD44+ CTEC及CTC、术后快速复发、SE-iFISH
      合作单位:北京协和医院外科、赛特生物
    • 61. H. Cheng, S. Wang, W. Luan, X. Ye, S, Dou, Z. Tang, H. Zhou, P.P. Lin, Y. Li, H. Cui, and X. Chang (2021) Combined detection and subclass characteristics analysis of CTCs and CTECs by SE-iFISH in ovarian cancer. Chin J Cancer Res 33:256-270

      关键词:卵巢癌诊断、CTC、SE-iFISH
      合作单位:北京大学人民医院妇产科、妇科肿瘤中心、赛特生物
    • 61R. H. Cheng et al. (2021) Preliminary Safety and Potential Effect of 6B11-OCIK Adoptive Cell Therapy Against Platinum-Resistant Recurrent or Refractory Ovarian Cancer. Front Immunol 12:707468.

      关键词:卵巢癌、细胞免疫治疗、CD31- CTC与CD31+ CTEC、SE-iFISH
      合作单位:北京大学人民医院妇产科、妇科肿瘤中心、赛特生物
    • 60. Y.Hong, J. Si, J. Zhang, Y. Xiong, J. Zhang, P. Lin, J. Fang, Y. Yang, C. Lv and Y. Ma (2021) Small Cell Size Circulating Aneuploid Cells as a Biomarker of Prognosis in Resectable Non-Small Cell Lung Cancer. Front Oncol 11:590952

      关键词:早期肺癌、术前CTC、小细胞三倍体CTC、预后
      合作单位:北京大学肿瘤中心、北京肿瘤医院胸外科及胸内科、赛特生物
    • 59.P. P. Lin (2020) Aneuploid Circulating Tumor-Derived Endothelial Cell (CTEC): A Novel Versatile Player in Tumor Neovascularization and Cancer Metastasis. Cells 9:1539

      关键词:CTEC、肿瘤细胞内皮化、肿瘤微环境、肿瘤新血管生成、肿瘤转移、hypoxia、EMT、EndoMT
      合作单位:赛特生物
    • 59R. Y. Lei, N. Sun, G. Zhang, C. Liu, Z. Lu, J. Huang, C. Zhang, R. Zang, R. Che, S. Mao, L. Fang, X. Wang, S. Zheng, J. He (2020) Combined detection of aneuploid circulating tumor-derived endothelial cells and circulating tumor cells may improve diagnosis of early stage non-small-cell lung cancer. Clin Transl Med e128

      关键词:肺癌早筛、肺小结节、CTEC、CTC、赛特SE-iFISH
      合作单位:中国国家癌症中心、中国国家临床肿瘤医学研究中心、中国医学科学院暨北京协和医学院肿瘤医院 – 赫捷院士、院长团队、赛特生物
    • 58. Y. Chen, C. Qi, J. Yuan, D. Liu, Z. Peng, X. Zhang, J. Li, P.P. Lin, Y. Li, L. Shen (2020) Elevated PD-L1 and HER2 expression on aneuploid carcinoma cells in malignant ascites accelerates tumor cell immune evasion in gastrointestinal cancer patients. Cancer Res 80:5381a

      关键词:恶性腹水肿瘤细胞、PD-L1、 HER2、免疫逃逸、胃癌
      合作单位:北京大学肿瘤中心、北京肿瘤医院、赛特生物
    • 57.  程洪艳,李一林,王书航,刘颖,王丹丹,林平,昌晓红 (2020) 应用SE-iFISH同步联合检测异倍体CTC与CTEC的重要临床意义。《临床实验室》(Clinical Laboratory) 14(5):43-48

      关键词:瘤标、异倍体、循环肿瘤血管内皮细胞CTEC、SE-iFISH
      合作单位:北京大学人民医院妇科肿瘤中心、北京大学肿瘤中心、北京肿瘤医院、中国国家癌症中心、中国医学科学院、北京协和医学院肿瘤医院 、赛特生物
    • 56. L. Zhang, X. Zhang, Y. Liu, T. Zhang, Z. Wang, M. Gu, Y. Li, D.D. Wang, W. Li, P.P. Lin (2020) PD-L1+ aneuploid circulating tumor endothelial cells (CTECs) exhibit resistance to the checkpoint blockade immunotherapy in advanced NSCLC patients. Cancer Lett 469:355-366

      关键词:非小细胞肺癌、PD-L1+ CTC 及 CTEC、免疫治疗耐药
      合作单位:首都医科大学附属北京胸科医院、北京大学肿瘤中心、北京肿瘤医院、赛特生物
    • 55. Y. Zhao, J. Li, D. Li, Z. Wang, J. Zhao, X. Wu, Q. Sun, P.P. Lin, P. Plum, A. Damanakis, F. Gebauer, M. Zhou, Z. Zhang, H. Schlosser, K-W Jauch, P.J. Nelson, C.J. Bruns (2020) Tumor biology and multidisciplinary strategies of oligometastasis in gastrointestinal cancers. Semin Cancer Biol 60:334-343

      关键词:肿瘤寡转移OMD、肿瘤微环境、CTC及CTEC
      合作单位:德国科隆大学、德国慕尼黑大学、上海复旦大学肿瘤中心、上海长海医院、赛特生物
    • 55R. G. Ma, Y. Jiang, M. Liang, J. Li, J. Wang, X. Mao, J. S. Veeramootoo, T. Xia, X. Liu, S. Wang (2020) Dynamic monitoring of CD45-/CD31+/DAPI+ circulating endothelial cells aneuploid for chromosome 8 during neoadjuvant chemotherapy in locally advanced breast cancer. Ther Adv Med Oncol 12:1-14

      关键词:新辅助化疗、乳腺癌、CTEC、CTC、赛特SE-iFISH
      合作单位:江苏省人民医院暨南京医科大学第一附属医院乳腺外科、江苏省乳腺疾病诊疗中心、江苏省妇幼保健医院、赛特生物
    • 54. X. Liu, J. Li, B. L. Cadilha, A. Markota, C. Voigt, Z. Huang, P. P. Lin, D. D. Wang, J. Dai, G. Kranz, A. Krandick, D. Libl, H. Zitzelsberger, I. Zagorski, H. Braselmann, M. Pan, S. Zhu,Y. Huang, S. Niedermeyer, C. A. Reichel, B. Uhl, D. Briukhovetska, J. Suárez, S. Kobold, O. Gires, and H. Wang (2019) Epithelial-type systemic breast carcinoma cells with a restricted mesenchymal transition are a major source of metastasis (SA Highlights). Science Advances 5, eaav4275

      关键词:乳腺癌转移、肿瘤动物模型、原代肿瘤细胞培养、EpCAM+ CTCs与DTCs、单细胞测序
      合作单位:上海交大附属上海第一人民医院、德国慕尼黑大学、GSK制药、复旦大学生科院、南京医科大学、赛特生物等
    • 53. Y. Wang, Y. Liu, L. Zhang, L. Tong, Y. Gao, F. Hu, P. P. Lin, B. Li, T. Zhang (2019) Vimentin expression in circulating tumor cells (CTCs) associated with liver metastases predicts poor progression-free survival in patients with advanced lung cancer. J Cancer Res Clin Oncol 145:2911-2920

      关键词:SCLC及NSCLC、肺癌定向肝转移、预后、间质化CTC
      合作单位:首都医科大学附属北京胸科医院、赛特生物
    • 53R1. Z. Ye, Y. Ding, Z. Chen, Z. Li, S. Ma, Z. Xu, L. Cheng, X. Wang, X. Zhang, N. Ding, Q. Zhang, and Q. Qian (2019) Detecting and phenotyping of aneuploid circulating tumor cells in patients with various malignancies. Cancer Biol Ther 20:546

      关键词:普筛多瘤种CTC、间质化小细胞CTC、SE-iFISH
      合作单位:上海白泽医学检验所、上海细胞治疗集团研究中心、二军医大附属上海东方肝胆外科医院生物治疗中心、美国印第安纳大学医学院病理与临床检验中心
    • 53R2. Y. Zhang, J. Li, Li. Wang, P. Meng, J. Zhao, P. Hang, J. Xia, J. Xu, Li. Wang, F. Shen, A. Zheng, F. Zhou and R. Fan (2019) Clinical significance of detecting circulating tumor cells in patients with esophageal squamous cell carcinoma by EpCAM-independent enrichment and immunostaining-fluorescence in situ hybridization. Mol Med Rep 20:1551

      关键词:食管癌、新辅助化疗、术后CTC动态监测、预后评估、SE-iFISH
      合作单位:郑大一附院、河南安阳市肿瘤医院、上海张江转化医学中心、上海宝藤医学检验所
    • 52. Y. Li, X. Zhang, D. Liu, J. Gong, D. Wang, S. Li, Z. Peng, Y. Li, X. Wang, P. Lin, M. Li, and L. Shen (2018) Evolutionary expression of HER2 conferred by chromosome aneuploidy on circulating gastric cancer cells contributes to developing targeted and chemotherapeutic resistance (CCR Highlights). Clin Cancer Res 24:5261-71

      关键词:胃癌、CTC HER2与组织 HER2、CTC与耐药及不良预后
      合作单位:北京大学肿瘤中心、北京肿瘤医院、美国奥克拉荷马大学医学中心、赛特生物
    • 51. P. Lin, J. Li, D. Wang, O. Gires, H. Wang (2018) EpCAM differentially expressed on circulating and disseminated tumor cells promotes tumor metastasis in breast cancer patients. Cancer Res 78:1059a

      关键词:乳腺癌转移、EpCAM+ CTCs和DTCs、疗效和预后
      合作单位:上海交大附属上海第一人民医院、德国慕尼黑大学、赛特生物等
    • 50. J. Zhang, H. Shi, T. Jiang, Z. Liu, P.P. Lin, and N. Chen (2018) Circulating tumor cells with karyotyping as a novel biomarker for diagnosis and treatment of nasopharyngeal carcinoma. BMC Cancer 18:1133

      关键词:鼻咽癌、CTC检测、肿瘤分期、化疗疗效、耐药
      合作单位:华西医院肿瘤中心、肿瘤放疗科及生物治疗国家重点实验室、赛特生物
    • 49. P. Lin (2018) Aneuploid CTC and CEC. Diagnostics 8(2):26(1-13)

      关键词:CTC与CTEC、染色体异常、SE-i•FISH、单细胞测序
      合作单位:赛特生物
    • 48. L. Wang, Y. Li, J. Xu, A. Zhang, X. Wang, R. Tang, X. Zhang, H. Yin, M. Liu, D. Wang, P. Lin, L. Shen, J. Dong (2018) Quantified postsurgical small cell size CTCs and EpCAM+ circulating tumor stem cells with cytogenetic abnormalities in hepatocellular carcinoma patients determine cancer relapse. Cancer Lett 412:99-107

      关键词:肝癌、术后复发、小细胞CTC、EpCAM+ CTC、CTM
      合作单位:清华大学附属北京清华长庚医院 – 董家鸿院士、院长团队、北京大学肿瘤中心、北京肿瘤医院、解放军301总医院、赛特生物
    • 48R1. X. Liu, Z. Zhang, B. Zhang, Y. Zheng, C. Zheng, B. Liu, S. Zheng, K. Dong, R. Dong (2018) Circulating tumor cells detection in neuroblastoma patients by EpCAM-independent enrichment and immunostaining-fluorescence in situ hybridization. EBioMedicine 35:244

      关键词:神经母细胞瘤、预后评估、转移诊断、SE-iFISH
      合作单位:复旦大学附属儿科医院、上海张江转化医学中心、上海宝藤医学检验所
    • 48R2. Z. Su, J. Zhao, S. KE, J. Zhang, X. Liu, Y. Wang, Q. Sun and Q. Pan (2018) Clinical significance of circulating tumor cells via combined whole exome sequencing in early stage cancer screening: A case report. Exp Ther Med 16:2527

      关键词:肿瘤早筛、结直肠癌、结肠息肉、单细胞CTC全外显子测序、SE-iFISH
      合作单位:福建泉州第一医院、上海张江转化医学中心、上海宝藤医学检验所
    • 47. X. Li, Y. Zhang, J. Ding, M. Wang, N. Li, H. Yang, K. Wang, D. Wang, P. Lin, M. Li, Z. Zhao, and P. Liu (2017) Clinical significance of detecting CSF-derived tumor cells in breast cancer patients with leptomeningeal metastasis. Oncotarget 9:2705-14

      关键词:乳腺癌脑转移、原代肿瘤细胞培养、NGS、指导个体化筛药
      合作单位:大连医科大学肿瘤干细胞研究所、大连医大第二附属医院、赛特生物
    • 46. P. Lin, O. Gires, D. Wang, L. Li and H. Wang (2017) Comprehensive in situ co-detection of aneuploid circulating endothelial and tumor cells. Sci Rep 7:9789

      关键词:CD31、异倍体循环血管内皮细胞CTEC、肿瘤血管生成、CTC活性
      合作单位:上海市第一人民医院肿瘤中心、德国慕尼黑大学、赛特生物
    • 46R. Y. Xu, T. Qin, J. Li, X. Wang, C. Gao, C. Xu, J. Hao, J. Liu, S. Gao and H. Ren (2017) Detection of Circulating Tumor Cells Using Negative Enrichment Immunofluorescence and an In Situ Hybridization System in Pancreatic Cancer. Int J Mol Sci 18:622

      关键词:胰腺癌CTC、癌栓CTM、三倍体,CA19-9,化疗敏感与耐药、预后、SE-iFISH
      合作单位:中国国家临床肿瘤医学研究中心肿瘤防治重点实验室、天津医科大学肿瘤医院暨肿瘤研究所
    • 45. 由磊,赵烨,阚秀,李一林,王东民,张爱群,王红霞,刘颖,王丹丹,林平,郑直 (2017) 同步原位检测 CTC 多重瘤标蛋白表达与染色体异倍体的意义及应用。《临床与实验病理学杂志》 (J Clin Exp Pathol) 33:297-302

      关键词:液体活检、CTC、临床意义
      合作单位:北京协和医院、中国医学科学院基础医学研究所、北京肿瘤医院、解放军301医院、北京大学第一医院、赛特生物
    • 45R. W. Wu, Z. Zhang, X. Gao, Z. Shen, Y. Jing, H. Lu, H. Li, X. Yang, X. Cui, Y. Li, Z. Lou, P. Liu, C. Zhang, W. Zhang (2017) Clinical significance of detecting circulating tumor cells in colorectal cancer using subtraction enrichment and immunostaining-fluorescence in situ hybridization (SE-iFISH) Oncotarget 8:21639

      关键词:结直肠癌、术前与术后CTC、术后复发及预后、SE-iFISH
      合作单位:西安交大附属陕西汉中3201医院普外科、上海张江转化医学中心、二军医大附属长海医院结直肠癌外科
    • 44. Y. Li, X. Zhang, D. Liu, J. Gong, D.D. Wang, P.P. Lin, and L. Shen (2017) Dynamic acquisition of HER2 expression on circulating tumor cells in gastric cancer patients correlates to developing therapeutic resistance. Cancer Res 77:3795a

      关键词:胃癌、HER2+ CTC、耐药
      合作单位:北京大学肿瘤中心、北京肿瘤医院、美国奥克拉荷马大学医学中心、赛特生物
    • 44R. Y. Sheng, T. Wang, H. Li, Z. Zhang, J. Chen, C. He, Y. Li, Y. Lv, J. Zhang, C. Xu, Z. Wang, C. Huang and L. Wang (2017) Comparison of analytic performances of Cellsearch and iFISH approach in detecting circulating tumor cells. Oncotarget 8:8801

      关键词:乳腺癌、CellSearch 阳性率 38%、SE-iFISH 阳性率 91%
      合作单位:第二军医大学附属上海长海医院、第四军医大学附属西安西京医院、上海张江转化医学中心、上海宝藤医学检验所
    • 43. H. Wang, N. Stoecklein, P. Lin and O. Gires (2017) Circulating and disseminated tumor cells: diagnostic tools and therapeutic targets in motion (Review). Oncotarget 8:1884-1912

      关键词:CTC与DTC检测、治疗靶标
      合作单位:上海交通大学附属上海市第一人民医院肿瘤中心、德国慕尼黑大学、赛特生物
    • 42. Y. Li, X. Zhang, J. Gong, Q. Zhang, J. Gao, Y. Cao, D. D. Wang, P.P. Lin, and L. Shen (2016) Aneuploidy of chromosome 8 in circulating tumor cells correlates with prognosis in patients with advanced gastric cancer. Chin J Cancer Res 28:579-588

      关键词:晚期胃癌、8号染色体异倍体、CTC、预后
      合作单位:北京大学肿瘤中心、北京肿瘤医院、赛特生物
    • 42R. Y. Gao, Y. Zhu, Z. Zhang, C. Zhang, X. Huang and Z. Yuan (2016) Clinical significance of pancreatic circulating tumor cells using combined negative enrichment and immunostaining-fluorescence in situ hybridization. J Exp Clin Cancer Res 35:66

      关键词:胰腺癌、局部与转移、预后、SE-iFISH
      合作单位:上海交通大学附属上海市第六人民医院、上海张江转化医学中心、上海宝藤医学检验所
    • 41. P. Lin (2016) NGS analysis of the single CTC or DTC isolated and subtyped by the integrated subtraction enrichment and immunostaining-FISH. Cancer Res 76:489a

      关键词:EMT、差相富集 、CTC亚类
      合作单位:赛特生物
    • 41R. F. Gao, Y. Cui, H. Jiang, D. Sui, Y. Wang, Z. Jiang, J. Zhao, S. Lin (2016) Circulating tumor cell is a common property of brain glioma and promotes the monitoring system. Oncotarget 7:71330-71340

      关键词:胶质瘤、CTC、疗效评估、赛特SE-iFISH
      合作单位:首都医科大学附属北京天坛医院、中国国家神经系统疾病临床医学研究中心、北京脑重大疾病研究院、北京脑肿瘤研究重点实验室、北京清华大学第一附属医院
    • 40. P. Lin (2015) Integrated EpCAM-independent subtraction enrichment and iFISH strategies to detect and classify disseminated and circulating tumors cells. Clin Transl Med 4(38):1-7

      关键词:SE-iFISH、CTC分类、临床意义
      合作单位:赛特生物
    • 39. F. Ge, H. Zhang, D. Wang, L. Li and P. Lin (2015) Enhanced detection and comprehensive in situ phenotypic characterization of circulating and disseminated heteroploid epithelial and glioma tumor cells. Oncotarget 6 (29): 27049-27064

      关键词:CTC 和 DTC 亚型、差相富集 (SE)、原位表型和核型分析 (iFISH)
      合作单位:北京朝阳医院、复旦大学华山医院、赛特生物
    • 38. P. Lin, L. Li, and D. Wang (2015) A novel integrated iFISH technology to detect and characterize non-hematopoietic heteroploid CTC subtypes with or without expressing vimentin or other tumor biomarkers. Cancer Res 75:557

      关键词:iFISH 技术、检测并分型 CTC
      合作单位:赛特生物
    • 37. J. Jiang, D. Wang,  M. Yang, D. Chen, L. Pang, S. Guo, J. Cai, J.P. Wery, L. Li, H. Li,and P. Lin (2015) Comprehensive characterization of chemotherapeutic efficacy on metastases in the established gastric neuroendocrine cancer patient derived xenograft model. Oncotarget 6(17):15639-15651

      关键词:CTC 亚型、转移性 PDX、耐药、表型和核型分析 (iFISH)
      合作单位:北京大学天然药物与仿生药物国家重点实验室、中美冠科生物技术有限公司、赛特生物
    • 36. Y.Li, X. Zhang, S. Ge, J. Gao, J. Gong, M. Lu, Q. Zhang, Y. Cao, D. Wang, P. Lin, L. Shen (2014) Clinical Significance of Phenotyping and Karyotyping of Circulating Tumor Cells in Patients with Advanced Gastric Cancer. Oncotarget  5(16):6594-6602

      关键词:胃癌、CTC、核型分析、耐药监测
      合作单位:北京大学肿瘤中心、北京肿瘤医院、赛特生物
    • 35. R. Ran, L. Li, M. Wang, S. Wang, Z. Zheng, and P. Lin (2013) Determination of EGFR mutation in single cells microdissected from enriched lung tumor cells in peripheral blood. Anal. Bioanal. Chem. 405(23):7377-7382

      关键词:肺癌、CTC、单细胞测序、EGFR 突变
      合作单位:北京协和医院、中国医学科学院基础医学研究所、赛特生物
    • 34. J. Jiang, D.D. Wang, M. Yang, D. Chen, S. Guo, J. Cai, L. Li, J-P. Wery, P. Lin, and H. Li (2013) Metastatic PDX modeling displays correlation between CTC and metastatic potential, both inhibited by chemotherapy. Mol. Cancer Ther. 12:157

      关键词:PDX 模型、CTC 、转移潜能
      合作单位:中美冠科生物技术有限公司、赛特生物
    • 33. Q. Chen, F. Ge, W. Cui, F. Wang, Z. Yang, Y. Guo, L. Li, R. Bremner, and P. Lin (2013) Lung Cancer Circulating Tumor Cells Isolated by the EpCAM-Independent Enrichment Strategy Correlate with Cytokeratin 19-Derived CYFRA21-1 and Pathological Staging. Clin. Chim. Acta 419:57-61

      关键词:肺癌、CTC、病理分期、CYFRA21-1
      合作单位:北京协和医院、世纪坛医院、圣约瑟夫医院、赛特生物
    • 32. 杨俊俊,徐兴祥,闭凌峰,林平,钱桂生 (2012) 免疫磁珠阴性法富集恶性胸腔积液中肿瘤细胞方法的建立。《中华结核和呼吸杂志》(Chin J Tuberc Respir Dis) 35(9):673-678

      关键词:肺癌、恶性胸水、回收率、SE-iFISH
      合作单位:扬州大学苏北人民医院、解放军88医院、第三军医大学新桥医院、赛特生物
    • 31. X. Zhou, L. Li, H. Hao, S. Wang, Z. Guo, M. Wang, L. Zhang, W. Zhong, R. Ran, X. Zhang, L. Xu, and P. Lin (2010) Circulating tumor cells as a prognostic and predictive indicator in advanced lung cancer patients. Oncol. Progress 8(5):484-490

      关键词:肺癌、CTC、疗效
      合作单位:北京协和医院、首都医科大学附属北京胸科医院、赛特生物
    • 30. C. Wu, H. Hao, L. Li, X. Zhou, Z. Guo, L. Zhang, X. Zhang, W. Zhong, H. Guo, R. Bremner, and P. Lin (2009) Preliminary investigation of the clinical significance of detecting circulating tumor cells enriched from lung cancer patients. J. Thorac. Oncol. 4:30-36

      关键词:循环肿瘤细胞 (CTC) 、肺癌、CT、化疗疗效评估、复发
      合作单位:北京协和医院、北京微生物与流行病研究所、赛特生物
    • 29. P. Lin, C. Lavoie, T. Fischer, H. Huang, and M. Farquhar (2009) Calnuc plays a role in dynamic distribution of Galphai but not Gbeta subunits and modulates ACTH secretion in AtT-20 neuroendocrine secretory cells. 
      Mol. Neurodegener. 4:1-16

      关键词:G-蛋白、调节性细胞外泌
    • 28. L. Li, X. Zhou, H. Hao, M. Wang, Z. Guo, S. Wang, X. Xing, G. Harvie, E. Vuong, W. Shi, M. Tang, J. Rao, T. Reid, R. Bremner, P. Lin, J. Xu (2008) Detection of circulating tumor cells in newly diagnosed or relapsed lung cancer patients and the significance of CTC enumeration in patient staging. Cancer Res. 68:3691

      关键词:非小细胞肺癌、CTC 计数、临床分期、影像学
      合作单位:加州大学洛杉矶分校、加州大学圣地亚哥分校、圣约瑟夫医院、赛特生物
    • 27. D. Wang, Y, Liu, Y. Liu, C. Wang, H. Bao, H. Hao, S. Wang, Y. Zhang, H. Yu, X. Xing, G. Harvie, E. Vuong, J. Rao, T. Reid, P. Lin, J. Xu (2008) Enrichment and detection of circulating tumor cells in breast cancer patients. Cancer Res. 68:3692

      关键词:乳腺癌、分期与疗效、CTC 计数
      合作单位:北京大学第一医院、加州大学圣地亚哥分校、赛特生物
    • 26. H. Guo, H. Hao, Z. Li, Y. Zhu, J. Sun, F. Ge, S. Wang, X. Xing, G. Harvie, E. Vuong, J. Rao, R. Bremner, T. Reid, P. Lin, J. Xu (2008) Preliminary investigation of lung cancer CTC distribution in patient body circulation. Cancer Res. 68:3694

      关键词:肺静脉、桡动脉和外周血 CTC 、显著性差异
      合作单位:北京协和医院、加州大学圣地亚哥分校、赛特生物
    • 25. Y, Chen, H. Bao, C. Zhou, X. Xing, G. Harvie, E. Vuong, J. Rao, T. Reid, H. Qiu, Y. Xiao, H. Wu, M. Mei, C. Lu, P. Lin and J. Xu (2008) Detection of circulating tumor cell in patients with colorectal cancer and its potential implication. Cancer Res. 68:3696

      关键词:结直肠癌、CTC、肿瘤侵袭性
      合作单位:北京协和医院、加州大学圣地亚哥分校、加州大学洛杉矶分校、赛特生物
    • 24. X. Zhou, L. Li, M. Wang, L. Zhang, P. Lin and J. Xu (2008) Circulating tumor cells (CTC) as a prognostic and predictive factor in lung cancer patients. J Clin Oncol 26(15):22201

      关键词:肺癌、CTC、预后
      合作单位:北京协和医院、赛特生物
    • 23. C. Ren, P. He, J. Zhang, Z. Zheng, Y. Xu, L. Zhou, H. Qiao, C. Wang, P. Zhao, W. Shi, M. Tang, P. Lin, and J. Xu (2007) Detecting circulating tumor cells in peripheral blood of pancreatic cancer patients using negative selection strategy. Cancer Res. 67:5445

      关键词:差相富集、CTC、胰腺癌
      合作单位:中国国家癌症中心、中国国家临床肿瘤医学研究中心、中国医学科学院肿瘤医院、赛特生物
    • 22. W. Shi, T. Reid, M. Tang, G. Harvie, H. Tao, G. Tao, P. Lin, and J. Xu (2007) Detection of circulating cancer cells from lung cancer patient blood samples and correlation with anti-cancer therapy. Cancer Res. 67:5444

      关键词:肺癌、CTC、化疗
      合作单位:北京协和医院、加州大学圣地亚哥分校、赛特生物
    • 21. H. Yu, P. Lin, Y. Xu, Y. Zhou, Q. Sun, and J. Xu (2007) Breast cancer and circulating tumor cells (Review). Chn. J. Med. Lab. Tech. 8(3):215-218

      关键词:乳腺癌、循环肿瘤细胞
      合作单位:北京协和医院、赛特生物
    • 20. Y. Chen, P. Lin, S. Qiu, XX. Peng, K. Loi, MG Farquhar and JY. Zhang (2007) Autoantibodies to Ca2+ binding protein Calnuc is a potential marker in colon cancer detection. Int. J. Oncol. 30(5):1137-44

    • 19. P. Lin, F. Li, Y. Zhang, H. Huang, G. Tong, M. Farquhar and H. Xu (2007) Calnuc binds to Alzheimer’s beta-amyloid precursor protein and affects its biogenesis. J. Neurochem. 100:1505-1514

    • 18. Y. Chen, P. Lin, K. Looi, R. Megliorino, and J. Zhang (2005) Autoantibodies to calcium binding protein Calnuc might be a potential marker in colon cancer detection. Cancer Res. 65:561

    • 17. P. Lin, C. Ren, X. Zhao, L. Li, Y. Qiao , G. Harve, H. Tao, E. Vuong, G. Tao, M, Huang, L. Wu, and J. Xu (2005) Role of detecting circulating tumor cell in clinical cancer diagnosis and therapy. Chn. J. Lab. Tech. 1 (1):1-6

      关键词:循环肿瘤细胞检测、临床肿瘤诊断和治疗
      合作单位:中国国家癌症中心、中国国家临床肿瘤医学研究中心、中国医学科学院肿瘤医院、北京协和医院、赛特生物
    • 16. Y-W. Zhang, W-J Luo, H. Wang, P. Lin, K.S. Vetrivel, F. Liao, F. Li, P.C. Wong, M.G. Farquhar, G. Thinakaran, and H. Xu (2005) Nicastrin is critical for stability and trafficking but not association of other presenilin/γ-secretases components. J. Biol. Chem. 280:17020-17026

    • 15. C. Lavoie, T. Meerloo, P. Lin , and M.G. Farquhar (2002) Calnuc, an EF-Hand Ca2+-binding protein, is stored and processed in the Golgi and secreted by the constitutive-like pathway in AtT-20 cells. Mol. Endocrinol. 16:2462-2474

    • 14. T.S.Weiss, C.E. Chamberlain, T. Takeda, P. Lin, K.M. Hahn, and M.G. Farquhar (2001) Galphai3 binding to calnuc on Golgi membranes in living cells monitored by fluorescence resonance energy transfer (FRET) of green fluorescent protein fusion proteins. Proc. Natl. Acad. Sci. USA. 98:14961-14966

    • 13. P. Lin, T. Fischer, T. Weiss, and M.G. Farquhar (2000) Calnuc, an EF-hand Ca2+ binding protein, specifically interacts with the C-terminal alpha5-helix region of Galphai3. Proc. Natl. Acad. Sci. USA. 97:674-679

    • 12. P. Lin, C. Lavoie, T. Fischer and M.G. Farquhar (2000) Calnuc regulates ACTH secretion in AtT-20 cells. Mol. Biol. Cell 11:50

    • 11. P. Lin, Y. Yao, R. Hofmeister, R.Y. Tsien and M.G. Farquhar (1999) Overexpression of CALNUC (nucleobindin) increases agonist and thapsigargin relesable Ca2+ storage in the Golgi. J. Cell Biol. 145:279-289

    • 10. P. Lin, T. Fischer, T. Weiss, and M.G. Farquhar (1999) Calnuc, an EF-hand Ca2+ binding protein, specifically interacts with the C-terminal region of Galphai3. Mol. Biol. Cell 10:418

    • 9.P. Lin, H. Le-Niculescu, R. Hofmeister, J.M. McCaffery, M. Jin, H. Hennemann, T. McQuistan, L. De Vries, and M.G. Farquhar (1998) The mammalian Ca2+ binding protein, nucleobindin (CALNUC), is a Golgi resident protein. J. Cell Biol. 141:1515-1527

    • 8.P. Lin, Y. Yao, R. Hofmeister, R.Y. Tsien and M.G. Farquhar (1998) Overexpression of CALNUC increases agonist and thapsigargin relesable Ca2+ storage in the Golgi. Mol. Biol. Cell 9:99

    • 7. H. Le-Niculescu, P. Lin, M. Jin, H. Hennemann, D. Heinegard, T. McQuistan, J. M. McCaffery, N. Watson, L. De Vries, and M.G. Farquhar (1997) Characterization of a Golgi-associated EF-hand/ Ca2+ binding protein that interacts with heterotrimeric Galphai protein subunits. Mol. Biol. Cell 8:338

    • 6. Y-P. Li, G. Curley, M. Lopez, M Chavez, R. Glew, A. Aragon, H. Kumar, and O.G. Baca (1996) Protein-tyrosine phosphatase activity of Coxiella Burnetii that inhibits human neutrophils. Acta Virologica 40:263-272

    • 5. P. Lin, C. Mold, and T.W. DuClos (1995) Characterization of the C-reactive protein (CRP) receptor on the human monocytic cell line THP-1 (704). Immunol. Today 16(7):305-62

    • 4. O.G. Baca, Y-P. Li, and H. Kumar  (1994) Survival of the Q fever agent Coxiella Burnetii in the phagolysosome. Trends in Microbiol. 2(12):476-480

    • 3. Y-P. Li, C. Mold, and T.W. DuClos (1994) Sublytic Complement Attack Exposes C-Reactive Protein Biding Sites on Cell Membranes. J. Immunol. 152:2995-3005

    • 2. T. Nakagaki, P. Lin, and W. Kisiel (1992) Activation of human factor VII by the prothrombin activator from the venom of Oxyuranus Scutellatus(taipan snake). Thrombosis Res. 65:105-116

    • 1. P. Lin, Q.S. Lin, and S.Q. Nie (1992) Primary study of application of liposome immunolysis assay on drug monitoring. Prog. Clin. Biochem.p515-516. Editors: K. Miyai, T. Kanno, and E. Ishikawa. Excerpta Medica Publishing.

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